USE OF HYDROXYPROLINES FOR PRODUCING A MEDICINAL PRODUCT FOR INHIBITING LEUCOCYTE INVASION IN TISSUE

摘要

An agent for inhibiting leukocyte invasion of tissues contains a hydroxyproline derivative of formula (I), in which R1 and R2 may be the same or different and stand for hydrogen, alkyl groups with 1 to 10 C atoms or an acyl group with 1 to 8 C atoms, R3 stands for a hydroxy, alkoxy or amino group which may have 1 or 2 alkyl substituents with 1 to 4 C atoms or 1 or 2 aryl substituents with 6 to 10 C atoms. Also disclosed is a pharmaceutically acceptable salt of this compound, optionally with other usual pharmaceutical additives and/or auxiliary substances. This agent is useful to prevent and heal damages to tissues caused by invasion and activation of leukocytes.