COMBINED USE OF CHEMOKINE IP-10 AND INTERLEUKIN 12 IN THE PREPARATION OF COMPOSITIONS FOR THE TREATMENT OF MALIGNANT TUMORS

摘要

The invention concerns the combined use of chemokine IP-10 and interleukin 12 as therapy against malignant tumors and the use of IP-10 to potentiate the anti-tumoral effect of IL-12. Said substances are immunomodulating proteins enhancing anti-tumoral response. Combined administration of both substances to mammals makes it possible to enhance anti-tumoral activity in the tumor carrying mammal. Administration of both substances can be realized by means of a recombinant protein prepared in-vitro or by means of expression systems or gene transfer expressing said substances. The combination of both substances has a synergistic effect in the specific induction of cytotoxic lymphocytes against tumors. Combination of both substances in adequate proportions and dose can be useful in the treatment of any type of cancer, for instance adenocarcinoma of the colon.