BIODEGRADABLE POLYMER MATRICES FOR THE PROLONGED RELEASE OF LOCAL ANESTHETIC AGENTS.

摘要

AN IMPROVED BIODEGRADABLE CONTROLLED LIBERATION SYSTEM IS DESCRIBED, THAT CONSISTS OF A POLYMERIC MATRIX THAT INCORPORATES A LOCAL ANESTHETIC FOR THE PROLONGED ADMINISTRATION OF THE LOCAL ANESTHETIC AGENT AND A METHOD FOR THE MANUFACTURE OF THE SAME. THE POLYMERS AND THE MANUFACTURING METHOD USED TO FORM THE PLAM ARE SELECTED ON THE BASIS OF THEIR DEGRADATION PROFILES: RELEASE OF THE TOPICAL ANESTHETIC OF A LINEAR WAY, CONTROLLED DURING A PERIOD OF TWO WEEKS WITH PREFERENCE AND DEGRADATION LIVE WITH A HALF LIFE LESS THAN SIX MONTHS, WITH MORE PREFERENCE TWO MONTHS, TO AVOID LOCATED INFLAMMATION. ALTERNATIVELY, AN ANTI-INFLAMMATORY CAN BE INCORPORATED IN THE POLYMER WITH THE LOCAL ANESTHETIC TO PREVENT INFLAMMATION.