USE OF A DEHYDROEPIANDROSTERONE DERIVATIVE TO ACCELERATE OR INCREASE THE REGENERATION OF THE EPITHELIUM OR THE REGENERATION OF THE ENDOTHELY OF A TISSUE.

摘要

THE PRESENT INVENTION REFERS TO THE USE OF A DEHYDROEPIANDROSTERONE (DHEA) DERIVATIVE, AS DESCRIBED HEREIN, OR A PHARMACEUTICALLY ACCEPTABLE SALT OF THE SAME, FOR THE PREPARATION OF A PHARMACEUTICAL COMPOSITION THAT ACCELERATES THE RE-EPITELIZATION OR RE-ENDOTELIZATION IN A SUBJECT THAT NEEDS IT. BETWEEN EXAMPLES OF RE-EPITELIZATION FOR WHICH THE INVENTION IS PARTICULARLY ADEQUATE, WITHOUT THE LISTING THAT FOLLOWS LIMITATION, THE RE-EPITELIZATION OF (A) THE SKIN AFTER SURGICAL WOUNDS; (B) CUTANEOUS ABRASIONS CAUSED BY MECHANICAL TRAUMA, CAUSTIC AGENTS OR BURNS; (C) THE CORNEA AFTER THE OPERATION OF CATARATA OR CORNEA TRANSPLANTATION; (D) THE MUCOUS EPITHELIUM (RESPIRATORY, GASTROINTESTINAL, GENITOURINARY, MAMMARY, ORAL, OCULAR, LIVER AND KIDNEY CAVITY) AFTER INFECTION, NON-PATHOLOGICAL ETHOLOGIES OF MEDICINAL THERAPY; (E) SKIN AFTER GRAFT; AND (F) RENAL TUBULES AFTER ACUTE TUBULAR NECROSIS. BETWEEN THE EXAMPLES OF REENDOTHELIZATION FOR WHICH THE INVENTION IS PARTICULARLY APPROPRIATE IS INCLUDED, WITHOUT THE FOLLOWING LISTING MUST BE INTERPRETED BY LIMITATION, THE RE-ENDOTHELIZATION (OR THE RECOVERY OF THE ENDOTHELIS, VASOS DE LAISOS DE LAGOSINE DE LAGOSINE DE LAGUINE DE LAGUINE DE LAGESINE DE LAGUINE SANGUINE DE LAES SANGUINE DE LAES SANGUINE DE LAES SANGUINE OF FIBRINE OR THE LISIS OR MECHANICAL ALTERATION OF THROMBES IN CORONARY ARTERIES. ACCORDING TO THE PRESENT INVENTION, THE TIME NEEDED FOR A COMPLETE REEPITELIZATION OR RE-ENDOTHELIZATION IMPROVES OR IS ACCELERATED BY ADMINISTRATION OF A DEHYDROEPIANDROSTERONE DERIVATIVE (DHEA).