BICYCLOPOLYAZAMACROCYCLOCARBOXYLIC ACID COMPLEXES, THEIR CONJUGATES, PROCESSES FOR THEIR PREPARATION, AND USE AS CONTRAST AGENTS

摘要

Complexes of bicyclopolyazamacrocyclocarboxylic acid with Gd, Mn or Fe ionsare disclosed. The complexes can be cova-lently attached to a biologically active molecule, e.g. an antibody orantibody fragment, to form conjugates. The complexes andconjugates are useful as contrast agents for diagnostic purposes. Processesfor preparing both the complex and conjugate are dis-closed.