FAT REGULATED GENES, USES THEREOF, AND COMPOUNDS FOR MODULATING SAME

摘要

The present invention relates to methods for identifying genes regulated byfat and their subsequent use in determining compositions for use in thetreatment of disease, by utilizing the identified genes and their proteins.The identified compositions regulate the expression of the fat regulated genesor modulate the activity of their protein products. The nucleotide and aminoacid sequences for METP, a novel mitochondrial carrier protein and FTF1, a fatresponsive transcription factor, are taught. The nucleotide sequence for A1BG,a plasma glycoprotein is taught. The nucleotide and amino acid sequences forhuman GPAT and rat GLOL are taught. Control sequences for human METP, GLOL,FTF1, SCD, GPAT and A1BG are taught. Polyunsaturated fatty acid regulationfunctions are taught for SCD1, SCD2, SCD, G6PD, GPAT, FAS, COMT, Apo A-1,INSIG1, FTF1, GLOL, A1GB, Spot-14, delta-3, delta-2-enoyl-CoA isomerase, andMETP.