A PROCESS FOR THE MANUFACTURE OF PHARMACEUTICAL TABLETS CONTAINING PAROXETINE HYDROCHLORIDE ANHYDRATE

摘要

Pharmaceutical tablets containing crystalline paroxetine hydrochlorideanhydrate are prepared using a process comprising an initial wet granulationprocess in which an aqueous granulation liquid is added to a mixture of saidanhydrate an excipients under high-shear conditions and the thus obtained wetgranules are dried using a fluidized bed technique to obtain a water activitywithin a specified range, after which the dried granules after addition offurther adjuvants are compressed into stable tablets each having an identicalcomposition.