GASTRIC ACID SECRETION INHIBITING COMPOSITION COMPRISING AN ACID SUSCEPTIBLE PROTON PUMP INHIBITOR AND AN H2 RECEPTOR ANTAGONIST

摘要

An oral pharmaceutical dosage form comprises pharmacologically effectiveamounts of an acid susceptible proton pump inhibitor or a salt thereof, an H2receptor antagonist or a salt thereof and a pharmaceutically acceptablecarrier. The dosage form is capable of raising gastric pH to above 4 withintwo hours after administration and to keep it at that level for at least 4hours. Also disclosed is a method of manufacture of the dosage form, its usein treating dyspepsia and infection by Helicobacter pylori, and a method oftreating disorders associated with gastric acid secretion.