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Compound targeted for specific cells with reduced systemic toxicity
Compound targeted for specific cells with reduced systemic toxicity
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机译:靶向具有降低的全身毒性的特定细胞的化合物
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摘要
The present invention relates to a compound to selectively kill or protect a target cell in a patient with reduced systemic toxicity, which comprises a compound of the formula: W-Z-X wherein, X is a toxic agent or protective agent; W is a biologically active molecule which is adapted to selectively bind the target cell directly or indirectly; and Z is a breakable linker which covalently links W and X together, wherein the linked W remains bioavailable and bioactive, whereby the breakable linker releases the toxic agent or protective agent into the cell.
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