The present invention relates to proteins that interact with other proteins of Saccharomyces cerevisiae. More specifically, the present invention relates to complexes of polypeptides or polynucleotides encoding the polypeptides, fragments of the polypeptides, antibodies to the complexes, Selected Interacting Domains (SID®) which are identified due to the protein-protein interactions, methods for screening for agents which modulate the interaction of proteins and compositions that are capable of modulating the protein-protein interactions, such as, for example, drug in pharmaceutical composition.
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