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Paramagnetic metal ion-based macrocylic magnetization transfer contrast agents and method of use
Paramagnetic metal ion-based macrocylic magnetization transfer contrast agents and method of use
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机译:基于顺磁性金属离子的大环磁化造影剂及其使用方法
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摘要
The present invention is directed, in general, to contrast agents (CA), and methods and systems of using such agents for producing image contrast based on a magnetization transfer (MT) mechanism. The CA comprises a tetraazacyclododecane ligand having pendent arms R, R', R'' and R''' that are amides having a general formula: -CR1H-CO-NH-CH2-R2. R1 includes organic substituents and R2 is not hydrogen. A paramagnetic metal ion (M) is coordinated to the ligand. The method, comprises subjecting a CA, in a sample, to a radio frequency pulse. The CA has pendent arms R, R', R'' and R''' comprising organic substituents and the ligand further includes a M and a water molecule. A signal is obtained by applying a radio frequency pulse at a resonance frequency of the water molecule. The magnetic resonance system, comprises a magnetic resonance apparatus and the CA, the agent containing a ligand having the above described general formula.
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