Helicobacter pylori antigens: fusion of fay 31 and hpa 44

摘要

The present invention concerns a pharmaceutical product, e.g. a vaccine composition or vaccine kit, which comprises Fay31 and HOP38 polypeptides. The invention also concerns a fusion polypeptide comprising both Fay31 and HOP38 amino acid sequences, as well as a nucleic acid encoding such a fusion polypeptide. In addition, the invention concerns a pharmaceutical product comprising separate nucleotide sequences respectively encoding Fay31 and HOP38 polypeptides, Fay31 together with HOP38 provides a synergistic combination that can be used to treat and/or reduce the risk of iHelicobacter pylori/i infection in a mammal.