Polypeptides or nucleic acids encoding these of a family of G-protein coupled receptors and their use for the diagnosis of treatment of disorders, for example skin disorders and their use for the identification of pharmacologically active substances

摘要

G protein coupled receptor polypeptide (I) is a sequence of 331 (S1), 321 (S2) or 325 (S3) amino acids, all fully defined in the specification, or their functional variants. Independent claims are also included for the following: (a) nucleic acid (II) that encodes (I); (b) cell containing (II) or transformed with a vector, knockout gene construct or expression cassette containing (II); (c) transgenic non-human mammal containing (II) (or vector, knockout gene construct or expression cassette) in its genome; (d) antibody (Ab), or its fragment, directed against (I) or (II); (e) test kit for identifying pharmacologically active substances comprising (I), (II), Ab, the cells or transgenic animals; (f) carrier-bound array of (I), (II), Ab or the cells; (g) diagnostic or therapeutic composition containing (I), (II), Ab and/or cells; (h) method for preparing (I) by expressing (II) in a cell; (i) method for preparing the transgenic animals by regenerating a transgenic embryonal stem cell containing (II); (j) method for preparing Ab by immunization; and (k) use of a similar receptor polypeptide (Ia), 330 amino acid sequence (S4) fully defined in the specification.