Intranasal formulation containing scopolamine and method of treating motion sickness

摘要

The present invention relates to pharmaceutical formulations containing scopolamine. More particularly, the invention relates to an intranasal gel formulation including scopolamine hydrobromide in a pharmaceutically acceptable carrier, most preferably an intranasal gel, at a pH at or below about 4.0, preferably at or below about 3.5, and a salt concentration below about 200 mM, with the gel solution incorporating polyvinylalcohol as a gelling agent. The intranasal formulations are particularly useful for preventing and/or treating nausea and/or vomiting associated with, for example, motion sickness.