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Prevention of beta-amyloid neurotoxicity by blockade of the ubiquitin-proteasome proteolytic pathway
Prevention of beta-amyloid neurotoxicity by blockade of the ubiquitin-proteasome proteolytic pathway
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机译:通过阻断泛素-蛋白酶体蛋白水解途径来预防β-淀粉样蛋白神经毒性
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摘要
Compositions and methods for inhibiting neurotoxic ubiquitin-proteasome proteolysis, and treatment of neurodegenerative disorders. In particular, a method of suppressing the neurotoxic effect of beta -amyloid peptide, by administering an inhibitor to block beta -amyloid peptide-mediated ubiquitin-proteasome proteolysis. Preferred inhibitors are inhibitors of ubiquitination, such as leucine-alanine dipeptide, and inhibitors of post-ubiquitination proteasome activity, such as lactacystin.
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