POLYMORPHISMS IN A iKLOTHO/i GENE

摘要

Methods and means are described for diagnosing a disease or a predisposition to disease by genotyping a iklotho/i gene from an individual and identifying the presence of one or more risk polymorphisms. These risk polymorphisms are associated either directly or indirectly with predisposition to a range of chronic diseases including osteoporosis, skin disorders, age-related disease, lung dysfunction and metabolic syndrome. Methods of treatment, kits for diagnostic purposes and an isolated iklotho/i gene including all or some of a range of polymorphisms are also described as well as methods of isolating molecules that modulate a iklotho/i gene.