COMPOUNDS HAVING AFFINITY FOR THE VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2 (VEGFR-2) AND ASSOCIATED USES

摘要

Novel compounds are provided that bind to VEGFR-2. The novel compounds have a peptide chain approximately 8 to 40 amino acids in length that binds to VEGFR-2, or are dimers of such peptide chains. The compounds are useful as probes for affinity screening and as angiogenesis imaging agents. In addition, those compounds that are antagonists of VEGFR-2 are useful in the treatment of diseases including cancer, retinopathy, rheumatoid arthritis and others. Pharmaceutical compositions and methods of use are provided as well.