首页> 外国专利> NOVEL SOLID BODY FORMS OF MESOPROGESTIN 11 beta -4E-(HYDROXYIMINOMETHYL)-PHENYL-17 alpha -METHOXYMETHYL-17 beta -METHOXY-ESTRA-4,9-DIEN-3-ONE

NOVEL SOLID BODY FORMS OF MESOPROGESTIN 11 beta -4E-(HYDROXYIMINOMETHYL)-PHENYL-17 alpha -METHOXYMETHYL-17 beta -METHOXY-ESTRA-4,9-DIEN-3-ONE

机译:甲前列素11β-[4E-(羟亚甲基甲基)-苯基] -17α-甲氧基甲基-17 beta -METHOXY-ESTRA-4,9-DIEN-3-ONE的新颖固体形式

摘要

The invention relates to novel solid body forms of mesoprogestin 11 beta -[4E-(hydroxyiminomethyl)-phenyl]-17 alpha -methoxymethyl-17 beta -methoxy-estra-4,9-dien-3-one (oxime J 867), particularly a highly pure and stable amorphous or highly crystalline form (ansolvate/anhydrate) of compound J 867. The invention also relates to methods for producing said novel solid body forms and to the use thereof in pharmaceutical compositions. The novel solid body forms are characterized by exhibiting a high degree of stability. The solid body forms of oxime J 867 can, in particular, be used in the area of fertility control and in hormone replacement therapy.
机译:本发明涉及中孕激素11β-[4E-(羟基亚氨基甲基)-苯基]-17α-甲氧基甲基-17β-甲氧基-estra-4,9-dien-3-one(肟J 867)的新型固体形式,特别是化合物J 867的高纯度和稳定的无定形或高度结晶形式(无溶剂化物/无水物)。本发明还涉及制备所述新型固体形式的方法及其在药物组合物中的用途。新型固体形式的特征在于表现出高度的稳定性。肟J 867的固体形式尤其可以用于生育控制和激素替代治疗领域。

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