NEW METHOD FOR PREPARATION OF AMORPHOUS CEFUROXIME AXETIL

摘要

Disclosed is a method for preparation of amorphous cefuroxime axetil. The amorphous cefuroxime axetil can be prepared by (a) obtaining a reaction mixture by reacting sodium cefuroxima with (R, S)-1-acetoxylethylbromide at -10 °C to 0 °C in the presence of at least crown ether catalyst; (b) extracting the resulting mixture with an suitable organic solvent, and then concentrating the obtained organic layer; (c) dissolving the obtained residue into an water-soluble organic acid; and (d) dropping the obtained solution in cooling water. The method of present invention can effectively provide amorphous cefuroxime axetil with high purity and yield and is easily handled.