A SOLUBLE BETA 2 MICROGLOBULIN (β2M)/HFE MONOCHAIN FOR BIOTECHNOLOGICAL AND THERAPEUTIC APPLICATIONS

摘要

A soluble beta2m/HFE monochain which is a polypeptide comprising human beta2m, or an analog or active fragment thereof, linked to the alphal-alpha3 domains of human HFE, or an analog or active fragment thereof, by means of a flexible linker peptide, or a functional derivative or salt of said polypeptide. This invention also relates to therapeutic interventions for iron overload disorders and chronic infections.