HELICOBACTER PYLORI PRIME AND BOOST VACCINATION COMPRISING CAGA AND NAP ANTIGENS

摘要

A method for immunising a mammal against H.pylori infection, comprising the administration of a first immunogenic composition as a mucosal priming dose and a second immunogenic composition as a parenteral boosting dose, wherein the first and second immunogenic compositions each comprise CagA and NAP antigens. The combination of CagA and NAP has been found to be particularly effective in raising mucosal and systemic humoral immune responses when administered according to a mucosal prime/parenteral boost regime.