首页> 外国专利> NOVEL FERROCENE-TYPE POLYCYCLIC HYDROCARBON DERIVATIVES, NOVEL FERROCENE-TYPE NAPHTHALENEDIIMIDE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, INTERCALTORS COMPRISING THESE DERIVATIVES AND METHOD OF ELECTROCHEMICALLY DETECTING GENE

NOVEL FERROCENE-TYPE POLYCYCLIC HYDROCARBON DERIVATIVES, NOVEL FERROCENE-TYPE NAPHTHALENEDIIMIDE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, INTERCALTORS COMPRISING THESE DERIVATIVES AND METHOD OF ELECTROCHEMICALLY DETECTING GENE

机译:新颖的二茂铁型多环烃衍生物,新颖的二茂铁型萘二酰亚胺衍生物,制备相同的方法,包含这些衍生物的夹层物和电化学检测基因的方法

摘要

It is intended to provide novel compounds which can be easily separated and purified after the completion of the synthesis thereof, can be obtained at a high yield and are useful as intercaltors for nucleic acid bases such as DNA and RNA constituting the double helix structure. The above object is achieved by providing novel ferrocene-type polycyclic hydrocarbon derivatives represented by the following formula (1): (1) wherein A represents a polycyclic hydrocarbon or its derivative; R1 represents C¿1-3? alkyl, etc.; R?2 and R3¿ represent each a group serving as an electron-donating group or an electron-attracting group in an aqueous solution; R4 represents C¿1-6? alkylene; and n and m are each from 0 to 2; provided that two identical groups in a molecule are different from each other and N bonded to R?1¿ has been optionally cationized.
机译:旨在提供新颖的化合物,其在完成其合成后可以容易地分离和纯化,可以高收率获得,并且可用作构成双螺旋结构的核酸碱基(例如DNA和RNA)的嵌入剂。通过提供由下式(1)表示的新型二茂铁型多环烃衍生物来实现上述目的:(1)其中A表示多环烃或其衍生物; R1代表C?1-3?烷基等; R 2和R 3分别表示在水溶液中用作供电子基团或吸电子基团的基团。 R4代表C?1-6?亚烷基n和m分别为0至2;前提是分子中两个相同的基团互不相同,并且与R 1 1′键合的N可选地被阳离子化。

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