INHIBITION OF RESTENOSIS USING A DNA-COATED STENT

摘要

Restenosis of arteries after angioplasty is inhibited by implanting in the treated artery a stent (100) incorporating genes (106) that encode gene products having anti-restenotic activity. The genes (106) may be incorporated into a coating (108) on the stent structure or in cells (114) that are affixed to the stent (100). The genes (106) or cells (114) containing them may be adhered to the struts (102) of the stent (100) or incorporated in a collagen matrix that forms a coating (110) covering the struts (102) and interstices (104) of the stent (100).