NURR1 TRANSCRIPTION FACTOR I-BOX MUTANTS HAVING MONOMERIC TRANSCRIPTIONAL ACTIVATION ACTIVITY

摘要

The invention relates to the finding that the Nurr1 transciption factor, which forms a heterodimer with the retinoid X receptor, can be mutated in the I box region such that dimerisation does not occur while Nurr1 transcriptional activation activity is retained. The invention provides Nurr1 peptides with such I box mutations, as well as assay methods for modulators which affect the monomeric activity of Nurr1.