METHOD OF DETECTING ETHIOLOGIC FACTOR OF BRONCHIAL ASTHMA

摘要

A means of detecting an ethiologic factor of human bronchial asthma, in particular, infant bronchial asthma. This means is characterized by detecting a specific polymorphism in human Iλβassociated protein gene, for example, a polymorphism associated with at least one amino acid mutation selected from the group consisting of, in the amino acid sequence of the human Iλβ-associated protein represented by SEQ ID NO:1, mutation of Ile at the 816-position into Leu, mutation of Ile at the 830-position into Met, mutation of Cys at the 1072-position into Ser and mutation of Pro at the 1158-position into Leu, or a polymorphism associated with at least one nucleic acid mutation selected from the group consisting of, in the code region of the human Iλβassociated protein gene represented by SEQ ID NO:2, mutation of T at the 819-position into C, mutation of G at the 2295-position into A, mutation of A at the 2446-position into C, mutation of A at the 2490-position into G, mutation of T at the 3214-position into A and mutation of C at the 3473-position into T, and a haplotype having such a mutation.