A METHOD FOR REDUCING HEPARIN INTERFERENCE IN DIAGNOSTIC TESTS FOR CARDIAC TROPONIN

摘要

The present invention is directed to a process for reducing heparin anticoagulant interference binding in antibody-antigen diagnostic assay, such as a diagnostic assay for cardiac Troponin I. The process utilizes a moiety, such as a highly charged peptide, which competes with heparin at the antibody-antigen binding site. Preferably, the moiety is a heparin antagonist such as a protamine salt or hexadimethrine bromide (polybrene).