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METHOD OF INDUCING VASODILATION AND TREATING PULMONARY HYPERTENSION USING ADENOVIRAL-MEDIATED TRANSFER OF THE NITRIC OXIDE SYNTHASE GENE
METHOD OF INDUCING VASODILATION AND TREATING PULMONARY HYPERTENSION USING ADENOVIRAL-MEDIATED TRANSFER OF THE NITRIC OXIDE SYNTHASE GENE
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机译:腺病毒介导的一氧化氮合酶基因诱导血管舒张和治疗肺动脉高压的方法
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摘要
This invention relates to a gene therapy method for inducing pulmonary vasodilation. More specifically, this invention involves introducing the nitric oxide synthase gene into lungs resulting in pulmonary vasodilation. This results in a hypotensive effect in the pulmonary circulation which does not significantly affect systemic blood pressure or cardiac index. This method is useful to treat primary pulmonary hypertension or pulmonary hypertension secondary to various disease states.
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