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Method of immortalization of human keratinocytes by down-regulation of 14-3-3 sigma expression

机译：通过下调14-3-3 sigma表达使人类角化细胞永生化的方法

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摘要

Immortalised cell lines from primary human keratinocytes cell lines obtained thanks to down regulation of 14-3-3-sigma coding gene. Said immortalised cell lines are extremely useful in in vivo and in vitro studies on cancer development. Infact, immortalization is absolutely required for somatic cells transformation. It is also an object of the present invention the immortalised cell lines obtained thereof.

机译：得益于14-3-3-sigma编码基因的下调，从原代人角质形成细胞获得永生化的细胞系。所述永生细胞系在体内和体外癌症发展研究中非常有用。实际上，永生化绝对是体细胞转化所必需的。本发明的另一个目的是获得其永生化细胞系。 展开▼

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公开/公告号EP1127942A8

专利类型

公开/公告日2002-01-16

原文格式PDF

申请/专利权人 PROVINCIA ITALIANA DELLA CONGREGAZIONE DEI FIGLI DELLIMMACOLATA CONCEZIONE - ISTITUTO DERMOPATICO DELLIMMACOLATA;
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申请/专利号EP20010830116

发明设计人 DELLAMBRA ELENA;DE LUCA MICHELE;
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申请日2001-02-21

分类号C12N15/11;C12N5/08;C07K14/47;C12Q1/02;

国家 EP

入库时间 2022-08-22 00:34:27

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