METHODS FOR IDENTIFYING DRUGS SPECIFIC FOR KNOWN MOLECULAR TARGETS USING MODEL COMPOUNDS SPECIFIC FOR THE MOLECULAR TARGETS

摘要

The present invention provides methods for identifying drugs that are most specific for their intended molecular targets utilizing compounds specific for the molecular targets as model drugs in cultured cells. In various embodiments, methods are described for use of the present invention to identify non-target effects of drugs. The present invention also provides methods to identify other molecular targets for disease intervention besides the intended molecular targets of the drugs. Compounds specific for their molecular targets are preferably antisense agents.