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ASSAYS FOR SCREENING COMPOUNDS WHICH INTERACT WITH CATION CHANNEL PROTEINS, MUTANT PROKARYOTIC CATION CHANNEL PROTEINS, AND USES THEREOF

机译：筛选与阳离子通道蛋白，突变原核阳离子通道蛋白相互作用的化合物的方法及其用途

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摘要

Assays for screening potential drugs or agents that can interact and potentially bind to cation channel proteins, and potentially have uses in treating conditions related to the function of cation channel proteins is provided, along with prokaryotic cation channel proteins mutated to mimic eukaryotic cation channels, which can then be used in assays of the present invention.

机译：提供了用于筛选可能与阳离子通道蛋白相互作用并可能与之结合并潜在用于治疗与阳离子通道蛋白功能有关的疾病的药物或试剂的检测方法，以及突变为模拟真核阳离子通道的原核阳离子通道蛋白。然后可以将其用于本发明的测定中。

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公开/公告号WO9947923A3

专利类型
公开/公告日2002-10-03

原文格式PDF
申请/专利权人 THE ROCKEFELLER UNIVERSITY;MACKINNON RODERICK;
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申请/专利号WO1999US06307
发明设计人 MACKINNON RODERICK;
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申请日1999-03-22
分类号G01N33/50;C07K14/195;C07K14/705;C07K16/12;C12N15/63;
国家 WO
入库时间 2022-08-22 00:34:14

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