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LIPID-BASED ARTIFICIAL PARTICLES INDUCING CELL-MEDIATED IMMUNITY

机译:基于脂质的人工颗粒诱导细胞介导的免疫

摘要

Artificial immunogenic particles (1), methods for producing the same and uses thereof are disclosed. The immunogenic particles (1) of the invention comprise a lipid-based matrix (3), glycolipids (5, 6) and peptide-lipid conjugates (7, 8) embedded into this matrix (3). These particles (1) are highly efficient in inducing cell-mediated immunity (CMI) when administered to a host. The immunogenic particles (1) of the invention can be used as immunostimulating agents (e.g. vaccines), and as immunotherapeutic agents for preventing and/or treating infectious diseases and cancers in which CMI responses play an important role.
机译:公开了人工免疫原性颗粒(1),其制备方法及其用途。本发明的免疫原性颗粒(1)包含基于脂质的基质(3),糖脂(5、6)和嵌入该基质(3)中的肽-脂质缀合物(7、8)。当施用于宿主时,这些颗粒(1)在诱导细胞介导的免疫(CMI)方面非常有效。本发明的免疫原性颗粒(1)可用作免疫刺激剂(例如疫苗),以及用作预防和/或治疗在其中CMI应答起重要作用的传染性疾病和癌症的免疫治疗剂。

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