A selectively-expressed epitope on the human CD38 molecule detected by a phage display library-derived human scFv antibody fragment

摘要

The present invention relates to antibodies and other binding molecules comprising a specificity for a selectively expressed CD38 epitope. Using a binding molecule of the invention it is, among others, possible to selectively mark a subset of CD38 expressing cells. An antibody or binding molecule of the invention is capable of binding to malignant B cells in a host thereby at least in part eliminating such malignant B cells from the body of the host. The invention among others provides pharmaceutical compositions, binding molecules, nucleic acids encoding binding molecules of the invention and gene delivery vehicles comprising said nucleic acid.