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INTERACTION BETWEEN THE VHL TUMOUR SUPPRESSOR AND HYPOXIA INDUCIBLE FACTOR, AND ASSAY METHODS RELATING THERETO
INTERACTION BETWEEN THE VHL TUMOUR SUPPRESSOR AND HYPOXIA INDUCIBLE FACTOR, AND ASSAY METHODS RELATING THERETO
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机译:VHL肿瘤抑制因子与低氧易感因子之间的相互作用及其相关评估方法
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摘要
The invention relates to the finding that the VHL tumour suppressor protein regulates hypoxia inducible factor subunits, by targeting HIF for destruction in normoxic, but not hypoxic cells. The invention provides assays for modulators of this interaction, and peptides based upon HIF subunit sequences which may modulate this interaction.
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