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Three compounds HNP-98701A HNP-98701B and HNP-98701C isolated from Saururus chinensis Baill as a potent anticancer agent and a process for preparation thereof and a pharmaceutical composition containing HNP-98701A HNP-98701B and HNP-98701C as an effective ingredient
Three compounds HNP-98701A HNP-98701B and HNP-98701C isolated from Saururus chinensis Baill as a potent anticancer agent and a process for preparation thereof and a pharmaceutical composition containing HNP-98701A HNP-98701B and HNP-98701C as an effective ingredient
The present invention relates to novel compounds derived from three hundred seconds HNP-98701A (epi-mana ssantin A, epi-manassantin A), HNP-98701B and HNP-98701C use and methods for their manufacture, and it is valid as an anticancer agent (mana ssantin A, manassantin A) relates to a pharmaceutical composition for cancer containing as components, specifically, it extracts the three hundred seconds with methanol and this again ethylacetate fraction a thin film chromatography (thin-layer chromatography) indicated the highest antitumor activity was fractionated in several organic solvents or column separated by chromatography (column chromatography), and high performance liquid chromatography (high performance liquid chromatography) the novel compound represented by the purified formula 4 and 5, to obtain the as HNP-98701A and HNP-98701B, compound HNP-98701C with its base derivatives, to a method for their preparation and pharmaceutical compositions for anticancer agents containing the same as an active ingredient. Compounds having anticancer activity according to the present invention HNP-98701A, HNP-98701B and HNP-98701C, so inducing cell death by apoptosis (apoptosis) by selectively acting as only the cancer cell-derived cell side effects for normal cells than the conventional anticancer drugs It flew the enemy has anticancer activity can be useful in the development of a very good alternative cancer.; Formula 4; Formula 5
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