1--2-- 1-ARENESULFONYL-2-ARYL-PYRROLIDINE AND PIPERIDINE DERIVATIVES FOR THE TREATMENT OF CNS DISORDERS

摘要

(RS)-2-phenyl-1-(toluene-4-sulfonyl)-pyrrolidine and (RS)-1-(Toluene-4-sulfonyl)-2-p-tolyl-pyrrolidine are excluded:;Formula 1;In this formula,;R^OneIs hydrogen, lower alkyl or hydroxy-lower alkyl,;R²Are furyl, thienyl, pyridyl or phenyl, which may be substituted by one or more substituents selected from the group consisting of lower alkyl, lower alkoxy, halogen, cyano, CF₃Or-N (R⁴)₂ RTI ID = 0.0 1, /RTI ;R³Lower alkyl, lower alkoxy, halogen, iscetyl, cyano, hydroxy-lower alkyl,-CH₂Morpholin-4-yl, lower alkyl-oxy-lower alkyl, lower alkyl-N (R⁴)₂Or CF₃ RTI ID = 0.0 1, /RTI ;R⁴Are each independently hydrogen or lower alkyl.;The compounds disclosed above are metabotropic glutamate receptor antagonists or agonists and are therefore useful in the treatment of corresponding CNS diseases.