/ : Specific autoimmune reactions against isomerised/optically inverted epitopes: application for diagnosis of autoimmune diseases

摘要

Antibodies and T lymphocytes that are immunoreactive with proteins that are isomerized from aspartic acid, asparagine, glutamine, or glutamic acid residues are associated with autoreactive autoimmune conditions in IgG (rheumatoid arthritis) and myelin basic protein (multiple sclerosis) It is known. Diagnostic analysis of autoimmune reactivity to isomerized protein sequences is described.