3 ADDUCTS OF SOLUBLE ALBUMIN WITH POLYHYDROXYLATED COMPLEXESPOLYALCOHOLS OF TRIVALENT IRON METHOD FOR OBTAINMENT AND PHARMACEUTICAL AND DIETETICAL PREPARATIONS CONTAINING THEM

摘要

PURPOSE: A process for obtaining the addition product by treating albumin suspension with sodium hydroxide and hydrogen peroxide and then adding with a polyhydroxylated complex of trivalent is provided. Thus obtained product can be effectively used for supplying and supplementing trivalent Fe to a human or animal requiring Fe. CONSTITUTION: Albumin suspension is reacted with sodium hydroxide at 63 to 67deg.C, agitated for 15min to 1hr, neutralized with an acid and then added with 4 to 8% by weight of hydrogen peroxide, based on the albumin, followed by washing and ultrafiltrating with a 10,000 Da ultrafiltration membrane. Thereafter, the treated albumin is mixed with a polyhydroxylated complex of trivalent Fe. The addition product has the following formula: £Fex(CxH2xOx)|n albumin(I) or £Fex(CxH2x+2O)n| albumin(II) in which x is an integer selected from 5, 6 or 12.