23--27- Pyrido23-dPyrimidine-27-Diamine Kinase Inhibitors

摘要

The present invention discloses compounds of formula (I);(I);Wherein, R ^2, R ^7, R ^13, R ¹⁴ and R ¹⁵ are independently hydrogen, (un) substituted lower alkyl, (un) alkenyl substituted lower alkenyl, (un) substituted lower alkynyl, or (un) substituted - (CH ₂ ) _n R ¹² ; R ⁵ is halogen, cyano, nitro, -R ⁹ , -NR ⁹ R ¹⁰ or -OR ⁹ ; R ⁶ is halogen, cyano, ^{nitro, -R 9, -NR 9 R 1O} , -OR 9, -C0 2 R 9, -COR 9, -CONR 9 R 10, -NR 9 COR 10, ( de) substituted Lower alkenyl or (un) substituted lower alkynyl; R ⁸ is _{^{-CO 2 R 13, -COR 13,}} -CONR 13 R l4, -CSNR l3 R l4, -C (NR 13) NR l4 R l5, -S0 3 R 13, -SO 2 R 13, -S0 ₂ NR ¹³ R ¹⁴ , -PO ₃ R ¹³ R ¹⁴ , -POR ¹³ R ^14, or -PO (NR ¹³ R ¹⁴ ) ₂ ; R ⁹ and R ¹⁰ are independently hydrogen or (un) substituted lower alkyl; R ¹¹ is a heteroaryl group or a heterocyclic group; R ¹² is a cycloalkyl group, a heterocyclic group, an aryl group or a heteroaryl group; n is 0, 1, 2 or 3;;These compounds and pharmaceutical compositions thereof are useful for the treatment of cell proliferative diseases such as cancer and restenosis. These compounds are potent inhibitors of cdk and growth factor-mediated kinase.