3--1--11- SELECTIVE CRYSTALLIZATION OF 3-PYRIDYL-1-HYDROXYETHYLIDENE-11-BISPHOSPHONIC ACID SODIUM AS THE HEMIPENTAHYDRATE OR MONOHYDRATE

摘要

The present invention relates to 3-pyridyl-1-hydroxyethylidene-1,1-bisphosphonic acid sodium hemipentahydrate and monohydrate, the hemipentahydrate and mono through control of nucleation temperature and crystallization rate. Methods of preparing hydrates and pharmaceutical compositions containing one or two of the above hydrate forms are disclosed.