1 Novel synthetic antimicrobial hybrid peptide derived from Ribosomal Protein L1 of Helicobacter pylori and use thereof

摘要

PURPOSE: Provided is a novel synthetic antibacterial hybrid peptide derived from Ribosomal Protein L1 of Helicobacter pylori and the use thereof. The synthetic antibacterial hybrid peptide has excellent antifungal and antibacterial activities without toxicity to remove bacteria which show antibiotics resistance. CONSTITUTION: The synthetic antimicrobial hybrid peptide is manufactured by hybridizing the amino terminal region of RPL1(ribosomal protein L1) protein produced by Helicobacter pylori with the amino terminal regions of melittin and magainin. The amino terminal region of RPL1(ribosomal protein L1) protein is represented by the SEQ ID NO:1, and the amino terminal regions of melittin and magainin are represented by SEQ ID NO:2 and SEQ ID NO:3 respectively.