The invention relates to a method for producing a recombinant endostatin efficiently by transfection using the draw small pillars melanocytes one requester (Drosophila melanogaster) cell switch S2. More specifically, the method of the present invention is draw small pillars melanocytes one requester transformed stably S2 cells with the recombinant plasmid in mouse endostatin gene is inserted, thereby efficiently expressing the recombinant endostatin at a much higher yield as compared to other conventional expression system relate to.
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