COMBINATION OF REUPTAKE INHIBITOR OF 5-HT WITH SELECTIVE 5-HT_1A ANTAGONIST

摘要

FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention concerns a combination of the first component (a) that is a reuptake inhibitor of 5-HT with the second component (b) that is a selective antagonist of 5-HT_1A of the formula (I) where R₁ means n-propyl or cyclobutyl; R₂ means isopropyl, tert. -butyl, cyclobutyl, cyclopentyl or cyclohexyl; R₃ means hydrogen atom; R₄ means hydrogen atom or methyl in the form of (R)-enantiomer as a free base or its pharmaceutically acceptable salts. Invention relates to also its synthesis, pharmaceutical preparations containing the indicated combination used for treatment of affective disorders. The described composition is more effective in treatment of affective states. EFFECT: valuable properties of inhibitor, enhanced effectiveness of combination. 19 cl, 1 dwg, 9 ex