METHOD OF SYNTHESIS OF 5-SUBSTITUTED-2-CYANO-FURANS

摘要

FIELD: organic chemistry, chemical technology. SUBSTANCE: invention relates to a method of synthesis of 5-substituted-2-cyanofurans of the general formula: where R is a hydrogen or bromine atom, methyl or nitro-group. Method involves an interaction of furan aldehyde of the formula: where R has the above indicated values with hydrazonic acid in chloroform medium, at heating, in the presence of hydrated magnesium perchlorate of the formula Mg(ClO₄)₂•2,5H₂O as a catalyst taken in the mole ratio of the corresponding furan aldehyde, hydrazonic acid and indicated catalyst = 1:1.1:1, respectively, in the range of boiling point values: on start at hydrazonic acid boiling point and then on chloroform boiling point up to nitrogen evolution ceasing. These compounds are used in synthesis of biologically active substances. EFFECT: improved and simplified method of synthesis, increased yield. 1 tbl, 3 ex