首页> 外国专利> A process for producing an extract having strong Antiinflammations-, Antiblutplättchenaggregations- and antifungal activity of Zingiber officinale and pharmaceutical compositions

A process for producing an extract having strong Antiinflammations-, Antiblutplättchenaggregations- and antifungal activity of Zingiber officinale and pharmaceutical compositions

机译:一种具有强生姜的抗炎,抗blutplättchenaggregates和抗真菌活性的提取物的生产方法以及药物组合物

摘要

A method of preparing an extract from IZingiber officinale/I, which is potent in anti-inflammation, anti-platelet aggregation and anti-fungal activity, includes the following steps: preparing a crude liquid from rhizomes of ginger by extraction with an organic solvent or supercritical COSB2/SB or by distillation with steam; introducing the crude liquid to a reverse phase chromatography column, and eluting the column with water, a first eluent and a second eluent having a polarity weaker than that of the first eluent but stronger than that of chloroform, so that a first eluate resulting from elution of the first eluent and a second eluate resulting from elution of the second eluent are obtained; removing the first eluent and the second eluent from the first eluate and the second eluate by evaporation, respectively, so that a first concentrated eluate and a second concentrated eluate are obtained as the potent extract. The final product or the crude liquid obtained in the first step may be incorporated into a pharmaceutical composition together with a suitable carrier or diluent.
机译:一种具有抗发炎,抗血小板聚集和抗真菌活性作用的姜的提取物的方法,包括以下步骤:通过提取从姜的根茎中制备粗制液体用有机溶剂或超临界CO 2 或通过蒸汽蒸馏;将粗液体引入反相色谱柱,并用水洗脱该柱,其极性比第一洗脱剂弱但比氯仿强的第一洗脱剂和第二洗脱剂,使得洗脱得到的第一洗脱液获得第一洗脱液和第二洗脱液洗脱得到的第二洗脱液;通过蒸发分别从第一洗脱液和第二洗脱液中除去第一洗脱液和第二洗脱液,从而获得第一浓缩洗脱液和第二浓缩洗脱液作为有效提取物。第一步中获得的最终产品或粗液体可以与合适的载体或稀释剂一起掺入药物组合物中。

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