Increasing viral replication and yield in cell cultures, useful e.g. for detecting residual hepatitis A in inactivated products, by blocking activation of RNaseL

摘要

Method for increasing viral replication and viral yield in cell cultures comprises blocking activation of RNaseL by adding to the culture medium an RNaseL inhibitor (I) or an inhibitor (II) of 2-5-oligoadenylate(2-5A) synthase.