New lactam-substituted pyrazolo(3,4-b)pyridine derivatives, are soluble guanylate cyclase stimulants useful e.g. for treating cardiovascular or central nervous system diseases, sexual dysfunction or inflammation

摘要

4-(Amino or acylamino)-5-(cyclic amido)-2-(1-(2-fluorobenzyl)-1H-pyrazolo (3,4-b) pyridin-3-yl)-pyrimidin-5-yl carbamate derivatives (I) are new. 4-(Amino or acylamino)-5-(cyclic amido)-2-(1-(2-fluorobenzyl)-1H-pyrazolo (3,4-b) pyridin-3-yl)-pyrimidin-5-yl carbamate derivatives (I) of formula (I) and their salts, isomers and hydrates are new. R1 = NH2 or (1-6C) alkylcarbonylamino; Q = a group completing a 5-7 membered saturated or partially unsaturated heterocyclyl, optionally (i) containing another N, O or S heteroatom, (ii) substituted by 1-5 further substituents selected from oxo, 1-6C alkyl, OH, 1-6C hydroxyalkyl and/or halo and/or (iii) fused with a 6-10C aryl ring or a 3-8C cycloalkyl ring (optionally having a two C linked via O). An Independent claim is included for the preparation of (I).