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Hybrid protein complexes relevant method of preparation, and their applications in the diagnosis, as a therapeutic agent or reagent, which is used in medicine
Hybrid protein complexes relevant method of preparation, and their applications in the diagnosis, as a therapeutic agent or reagent, which is used in medicine
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机译:杂合蛋白复合物的相关制备方法及其在诊断中的应用,作为治疗剂或药物,用于医学
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摘要
Hybrid protein complexes comprising the light chains and the variable regions and some of the constant regions of the immunoglobulin heavy chains and another protein homo - or heterodimer, their preparation process, as well as their applications as diagnostic agent, as a therapeutic agent or as a reagent which can be used in medical imaging. & br / said hybrid protein of the type comprising an immunoglobulin fragment, fused with another protein p, is constituted by a sequence of hybrid complex comprising: & br / . a base unit u is constituted by: & br / - two different peptide chains su1 and su2, su1 comprising the variable regions and constant of a light chain of an immunoglobulin and su2 comprising at least the variable regions and the ch1 region of a heavy chain of an immunoglobulin, which peptide chains su1 and su2 are interconnected by at least a disulfide bridge and & br / - at least one functional fragment of one of the two under - units of a dimeric protein p, fused by its end n - terminal to one of the peptide chains su1 or su2 = br / which base unit u is associated with a base unit u ', identical or different from the unit u, by means of - units of the protein p or a fragment of those -.
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机译:杂合蛋白复合物,包括免疫球蛋白重链的轻链和可变区以及一些恒定区,以及另一种蛋白同或异二聚体,其制备方法以及它们在诊断剂,治疗剂或应用中的应用可用于医学成像的试剂。 &包含与另一种蛋白质p融合的包含免疫球蛋白片段的类型的所述杂合蛋白质由杂合复合物的序列构成,所述杂合复合物的序列包括: br />。基本单元u由以下组成:两条不同的肽链su1和su2,其中su1包含免疫球蛋白轻链的可变区和常数,而su2至少包含免疫球蛋白重链的可变区和ch1区域,该肽链su1 su 2和su 2至少通过二硫键互连。 br />-二聚体蛋白p的两个下部-单元之一的至少一个功能片段,通过其末端n-末端与肽链su1或su2之一融合,其中u与之相连通过蛋白质p的-单位或这些蛋白质的片段-与单位u相同或不同的碱基单位u'。
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