LARGE, LATENT COMPLEXES OF TGF-BETA2 AND TGF-BETA3

摘要

The invention relates to large latent complexes of TGF- beta 2 and TGF- beta 3, and methods for isolating these. The complex consists of a dimerized form of TGF- beta 2 or TGF- beta 3, the appropriate latency associated peptide, and the latent TGF- beta 1 binding protein, referred to as LTBP. Also described is a protein which binds to all of TGF- beta 1, TGF- beta 2 and TGF- beta 3, but is immunologically distinct from LTBP, referred to as LTBP-2.