Biologically active peptides from functional domains of the bactericidal / the permeability increasing protein and their use

摘要

The present invention provides peptides having an amino acid sequnce that is the amino acid sequence of a human bactericidal/permeability-increasing protein (BPI) functional domain or a subsquence thereof, and variants of the sequence or subsequence thereof, having at least one of the BPI biological activities, such as heparin binding, heparin neutralization, LPS binding, LPS neutralization or bactericidal activity. The invention provides peptides and pharmaceutical compositions of such peptides for a variety of therapeutic uses.