New 1-(benzoheterocyclyl-alkyl)-4-(phenyl or pyridyl)-piperidines, are tumor necrosis factor-alpha synthesis inhibitors useful for treating autoimmune or inflammatory diseases or pain

摘要

1-(Benzoheterocyclyl-alkyl)-4-(phenyl or pyridyl)-piperidine derivatives (I) are new. Piperidine derivatives of formula (I) and their salts and solvates are new. X = CH or N; R1 = H, halo or CF3; R2, R3 = H or Me; m, n = 0 or 1; W = group completing: (i) a 6-membered aromatic or saturated ring containing 1 or 2 N heteroatoms (optionally substituted by 1 or 2 of 1-4C alkyl, 1-4C alkoxy or CF3); or (ii) a 6-membered aromatic or saturated ring containing one N, O or S heteroatom (optionally substituted by 1 or 2 1-4C alkyl). An Independent claim is included for the preparation of (I).